Chemical Biology • PAR/ADP-ribosylation • Proteomics
About me
I’m a PhD candidate in Chemical Biology at Johns Hopkins (Leung Lab), where I study poly(ADP-ribose) (PAR) and the enzymology of PARP1/2. My work focuses on developing chemical tools and mass-spectrometry workflows to identify PAR-binding sites and understand how PAR scaffolds nucleic-acid–associated processes.
I’m passionate about reproducible analysis (R/Python), structural biology visualization, and turning complex datasets into clear, testable hypotheses.
Research interests
- PAR readers and binding-site mapping (cleavable photocrosslinkers, proteomics)
- Enzymology of PARP1/2 and NAD+–driven signaling
- Nucleic acids, RNA-binding proteins, and biomolecular condensates
- Data-driven method development (FragPipe, DIA-NN, custom R pipelines)
Selected projects
- PARmap: proteomics probe + analysis framework to localize PAR-binding sites
- Domain-level enrichment + PTM overlap analyses for PAR-associated proteins
- Structure/sequence visualization of PAR interfaces (PyMOL, AlphaFold)
Outside the lab
I love long bike rides, hiking, and exploring the outdoors. When I’m not debugging a script, I’m probably wrenching on a bike or planning the next route.